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Tricyclic Antidepressants and Antihistamines: Why Their Combination Can Cause Anticholinergic Overload

Tricyclic Antidepressants and Antihistamines: Why Their Combination Can Cause Anticholinergic Overload

  • January 31, 2026
  • Kiera Masterson

Combining tricyclic antidepressants like amitriptyline with first-gen antihistamines like Benadryl can cause anticholinergic overload-leading to confusion, memory loss, and increased dementia risk. Learn why this dangerous combo still happens and what to do instead.

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