Tag: diphenhydramine

Tricyclic Antidepressants and Antihistamines: Why Their Combination Can Cause Anticholinergic Overload

• January 31, 2026
• Kiera Masterson

Combining tricyclic antidepressants like amitriptyline with first-gen antihistamines like Benadryl can cause anticholinergic overload-leading to confusion, memory loss, and increased dementia risk. Learn why this dangerous combo still happens and what to do instead.