Naltrexone Bupropion – Quick Guide
If you’ve heard of a pill that mixes two drugs to help with weight loss, you’re probably talking about naltrexone bupropion. It’s sold under brand names like Contrave, but the chemistry stays the same. One part blocks your brain’s reward signals, while the other boosts mood and reduces cravings. Put together, they can make it easier to stick to a healthier diet and exercise plan.
How the Combination Works
Naltrexone is a medication usually used for alcohol and opioid dependence. In this combo, it blocks certain receptors in the brain that tell you “I want more.” Bupropion, on the other hand, is an antidepressant that also lifts dopamine and norepinephrine levels, which can curb appetite and increase energy. When you take them together, the reward‑blocking effect of naltrexone pairs with the appetite‑suppressing effect of bupropion, giving a double‑hit on cravings.
The pills come in a fixed dose: each tablet contains 8 mg of naltrexone and 90 mg of bupropion. Doctors start you at a low dose and gradually increase it over several weeks. This slow ramp helps your body adjust and reduces the chance of side effects.
Who Should Use It and What to Watch For
Typical candidates are adults with a body‑mass‑index (BMI) of 30 or higher, or those with a BMI of 27‑29 who also have weight‑related health issues like high blood pressure or type 2 diabetes. It isn’t for everyone – people with uncontrolled high blood pressure, seizure disorders, or a history of eating disorders should avoid it.
Common side effects include nausea, headache, dry mouth, and constipation. Most people see these fade after the first few weeks. If you notice a rapid heartbeat, severe dizziness, or thoughts of self‑harm, stop the medication and call your doctor right away.
Because bupropion can raise blood pressure, your doctor will likely check your numbers before you start and during the titration phase. It’s also a bad idea to mix this combo with other drugs that affect serotonin or lower the seizure threshold.
Take the tablets exactly as prescribed – usually one tablet twice a day with meals. Skipping doses or taking extra pills won’t speed up results and can increase side‑effects. Pair the medication with a balanced diet and regular activity; the drug helps, but lifestyle changes are still the foundation of lasting weight loss.
In practice, many users report a noticeable drop in late‑night snacking and a steadier mood after a few weeks. Results vary, though – some people lose a few pounds, while others see more significant changes. Your doctor can help set realistic goals based on your health profile.
Bottom line: naltrexone bupropion can be a useful tool for weight management, but it works best when you’re ready to commit to healthier habits and stay in touch with your healthcare provider. If you think it might be right for you, talk to a doctor to get a personalized plan.
