Indomethacin: What It Is, How to Use It, and What to Watch For

Indomethacin is a prescription NSAID (non‑steroidal anti‑inflammatory drug) that helps reduce pain, swelling, and fever. Doctors often prescribe it for arthritis, gout attacks, tendonitis, and certain types of headache. If you’ve been told to take Indomethacin, you probably want to know how it works, the right dose, and what side effects might pop up.

Typical Uses and How It Works

Indomethacin blocks enzymes called COX‑1 and COX‑2, which are key players in making prostaglandins—chemicals that cause inflammation and pain. By lowering prostaglandin levels, the drug eases joint stiffness, reduces swelling, and brings down fever. Common reasons doctors pick Indomethacin include:

• Rheumatoid arthritis flare‑ups
• Gout attacks that cause sudden, intense joint pain
• Ankylosing spondylitis
• Acute bursitis or tendonitis
• Severe migraine when other meds fail

It’s taken by mouth as tablets, capsules, or a liquid, and sometimes given by injection in a hospital setting.

Dosage Basics and Safe Taking Tips

Adults usually start with 25‑50 mg two to three times a day. Your doctor may adjust the dose based on how you feel and any other health conditions you have. For gout, a short high dose (like 75 mg three times daily for a few days) can bring rapid relief, but you should never change the schedule on your own.

Here are a few practical pointers:

• Take Indomethacin with food or a full glass of milk to protect your stomach.
• Don’t crush or chew extended‑release tablets; swallow them whole.
• If you miss a dose, take it as soon as you remember—unless it’s almost time for the next one. In that case, skip the missed dose; don’t double up.
• Stay hydrated. Drinking enough water helps your kidneys handle the drug.

Always tell your doctor about other meds you’re on. Indomethacin can interact with blood thinners, certain blood pressure drugs, and other NSAIDs, raising the risk of bleeding or kidney problems.

Common Side Effects and When to Call the Doctor

Most people tolerate Indomethacin well, but a few side effects are pretty common:

• Stomach upset, nausea, or heartburn
• Headache or dizziness
• Rash or mild itching

If you notice any of these, a small snack with your dose often helps. However, watch out for serious signs that need medical attention:

• Severe stomach pain, black or bloody stools (possible ulcer)
• Sudden swelling of the face, lips, or tongue (allergic reaction)
• Vision changes, hearing loss, or ringing in the ears (rare but can happen)
• Unexplained weight gain, swelling in the ankles, or difficulty breathing (fluid retention)

Call your doctor right away if any of these appear.

Long‑term use of Indomethacin can raise the risk of heart problems, kidney damage, and gastrointestinal bleeding. For that reason, doctors usually keep the treatment period as short as possible and may suggest protective meds like a proton‑pump inhibitor if you need a longer course.

Final Takeaways

Indomethacin can be a powerful ally against painful inflammation when used correctly. Stick to the prescribed dose, take it with food, and keep an eye on your stomach and kidneys. Communicate openly with your healthcare provider about other medicines and any new symptoms. With these habits, you’ll get the relief you need while staying safe.